/* Published study reference · slate-blue Cambrian UI */
#pg-dosages{background:#fff;color:#293649;font-family:'DM Sans',Inter,Arial,sans-serif;min-height:100vh}
#pg-dosages .rd-hero{background:linear-gradient(126deg,#F4F7FB 0%,#E8EEF5 65%,#F7FAFC 100%);position:relative;overflow:hidden}
#pg-dosages .rd-hero::after{content:'';position:absolute;border:1px solid #dbe4ee;border-radius:50%;width:600px;height:600px;right:-200px;top:-255px;pointer-events:none;opacity:.7}
#pg-dosages .rd-hero .v2-subhero-inner{position:relative;z-index:1}
#pg-dosages .rd-hero h1 em{font-style:normal;color:#53718c}
#pg-dosages .rd-hero p{max-width:720px;color:#667589;font-size:15px;line-height:1.8;margin-top:17px}
.rd-hero-counts{display:flex;flex-wrap:wrap;gap:10px;margin-top:25px}
.rd-hero-counts span{display:flex;align-items:center;gap:8px;color:#596d83;font-size:11px;background:#fff;border:1px solid #dee6ee;border-radius:11px;padding:9px 13px}
.rd-hero-counts strong{font-size:19px;color:#314e6a}
.rd-wrap{max-width:1220px;margin:0 auto;padding:56px 26px 100px}
.rd-intro{display:grid;grid-template-columns:minmax(0,1.4fr) minmax(0,.9fr);align-items:center;gap:44px;margin:0 0 38px}
.rd-overline{font-size:10px;color:#536d85;font-weight:800;letter-spacing:2px;text-transform:uppercase}
.rd-intro h2,.rd-method h2{font-size:clamp(25px,3vw,35px);letter-spacing:-1.3px;font-family:Manrope,Inter,sans-serif;font-weight:800;color:#263649;margin:11px 0}
.rd-intro p{color:#677689;line-height:1.75;font-size:13px;max-width:570px}.rd-intro p b{color:#425a72}
.rd-intro-tip{border:1px solid #DCE5EF;background:#F2F6FB;padding:23px 24px;border-radius:15px;display:flex;gap:15px;align-items:flex-start}
.rd-tip-icon{background:#dfeaf5;color:#46637e;width:27px;height:27px;line-height:27px;text-align:center;border-radius:50%;font-weight:800;flex:none;font-style:normal;font-family:Georgia,serif}
.rd-intro-tip p{font-size:12px;line-height:1.7;margin:0;color:#4f647b}
.rd-controls{background:#F6F8FB;border:1px solid #E2E9F0;border-radius:19px;padding:21px;margin-bottom:24px}
.rd-search-field{height:50px;border-radius:11px;background:#fff;border:1px solid #d9e2ec;display:flex;align-items:center;gap:13px;padding:0 15px;color:#687d93}
.rd-search-field:focus-within{border-color:#587793;box-shadow:0 0 0 3px rgba(73,105,134,.1)}
.rd-search-field input{font:500 14px 'DM Sans',Inter,Arial,sans-serif;border:0;outline:0;width:100%;color:#2b3e51;background:transparent;min-width:0}
.rd-search-field input::placeholder{color:#95a1af}
.rd-controls-label{color:#6a7c8e;font-size:9px;letter-spacing:1.5px;font-weight:800;margin:20px 0 11px}
.rd-filters{display:flex;flex-wrap:wrap;gap:8px}
.rd-filter{border:1px solid #d6e0e9;padding:11px 14px;background:white;color:#50667b;font:700 11px 'DM Sans',Inter,sans-serif;border-radius:9px;cursor:pointer;white-space:nowrap;transition:background .15s,border-color .15s}
.rd-filter:hover{border-color:#57728d}.rd-filter.act{background:#46627d;color:#fff;border-color:#46627d}
.rd-filter span{background:#eff3f7;color:#48627a;padding:3px 6px;border-radius:6px;margin-left:7px}
.rd-result-line{display:flex;justify-content:space-between;gap:12px;font-size:10px;color:#687a90;font-weight:700;letter-spacing:.4px;margin:0 0 17px}
.rd-result-line span:last-child{letter-spacing:1.3px;font-size:9px}
.rd-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px;align-items:start}
.rd-card{border:1px solid #e0e7ef;border-radius:16px;overflow:hidden;box-shadow:0 5px 18px rgba(41,63,84,.04);background:#fff;min-width:0}
.rd-card[hidden]{display:none!important}
.rd-card-head{padding:17px;display:flex;gap:16px;align-items:center;background:linear-gradient(120deg,#f3f6fa,#e7eef5);border-bottom:1px solid #e0e8f0;min-height:138px}
.rd-card-thumb{width:98px;height:107px;border-radius:11px;background:radial-gradient(circle,#fff 10%,#e7edf3 100%);flex:none;display:flex;align-items:center;justify-content:center;overflow:hidden}
.rd-card-thumb img.vial-img{max-width:90%;max-height:105px;object-fit:contain;filter:none!important}
.rd-card-thumb svg{max-height:100px;max-width:85px}
.rd-card-ordinal{font-size:9px;letter-spacing:1.1px;color:#718399;font-weight:800}
.rd-card-head h3{font:800 20px/1.22 Manrope,Inter,sans-serif;letter-spacing:-.8px;color:#263950;margin:7px 0 10px;overflow-wrap:anywhere}
.rd-category-tag,.rd-card-category{font-size:10px;font-weight:700;color:#536f89;display:inline-flex;align-items:center;gap:6px}
.rd-category-tag:before,.rd-card-category:before{content:'';width:6px;height:6px;border-radius:50%;background:#7994ae}
.rd-card-body{padding:21px 20px 16px}
.rd-evidence{background:#f1f4f8;color:#577087;border:1px solid #e1e7ef;padding:6px 9px;border-radius:6px;font-size:9px;letter-spacing:.2px;font-weight:800;display:inline-flex;margin-bottom:22px}
.rd-evidence-trial{background:#e8eef5;color:#405e7d;border-color:#cfdae7}
.rd-stat-label{display:block;font-size:9px;letter-spacing:1.2px;color:#8493a5;font-weight:800;margin-bottom:9px}
.rd-stat{font-size:19px;letter-spacing:-.65px;line-height:1.36;font-weight:800;color:#2e455d;display:block;min-height:52px;max-width:100%;overflow-wrap:break-word}
.rd-context{color:#64788d;font-size:11px;line-height:1.55;padding:0 0 16px;margin-top:7px;border-bottom:1px solid #e6eaf0}
.rd-summary{color:#617187;font-size:12px;line-height:1.75;margin:17px 0;min-height:106px}
.rd-expand{border-top:1px solid #e3e9f0;margin-top:13px}
.rd-expand summary{cursor:pointer;color:#3e607f;font-size:11px;font-weight:800;list-style:none;display:flex;justify-content:space-between;align-items:center;gap:12px;padding:17px 0 2px}
.rd-expand summary::-webkit-details-marker{display:none}
.rd-expand summary:hover{color:#243e57}
.rd-expand-arrow{border:1px solid #d3dfec;border-radius:50%;width:29px;height:29px;display:flex;justify-content:center;align-items:center;font-size:14px;transition:transform .2s}
.rd-expand[open] .rd-expand-arrow{transform:rotate(135deg)}
.rd-expand-content{border-top:1px solid #e9eef4;margin-top:17px;padding-top:12px}
.rd-fact{padding:12px 0;border-bottom:1px solid #edf0f4}
.rd-fact>span{font-size:9px;letter-spacing:1px;font-weight:900;color:#657d95;text-transform:uppercase;display:block;margin-bottom:8px}
.rd-fact strong{font-size:12px;color:#2a425a;line-height:1.65;font-weight:700}
.rd-fact p{font-size:11.5px;line-height:1.7;color:#586f83}
.rd-reference-links{display:grid;gap:9px;margin-top:16px}
.rd-reference-links>span{font-size:9px;letter-spacing:1px;color:#72869a;font-weight:900}
.rd-reference-links>a{border:1px solid #e1e9f2;border-radius:8px;padding:10px 11px;background:#f8fafc;display:flex;gap:10px;align-items:center;justify-content:space-between;color:#3f5f7e;font-size:11px;font-weight:700;text-decoration:none;line-height:1.4}
.rd-reference-links>a:hover{border-color:#8da4b9}
.rd-actions{margin-top:17px}.rd-open-library{cursor:pointer;border:none;background:none;color:#3f617e;font:800 11px 'DM Sans',Inter,sans-serif;padding:6px 0}
.rd-method{margin-top:55px;background:#f4f7fa;border:1px solid #e3eaf1;padding:33px 34px;border-radius:18px}
.rd-method-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:22px;margin-top:25px}
.rd-method-grid article{background:white;border:1px solid #e2e9f0;padding:22px 20px;border-radius:12px}
.rd-method-grid article>span{font-size:10px;letter-spacing:1.5px;font-weight:800;color:#7890a8}
.rd-method-grid h3{font-size:14px;font-weight:800;color:#30485e;margin:10px 0 8px}
.rd-method-grid p{font-size:11.5px;line-height:1.75;color:#67788b}
.rd-method-actions{display:flex;flex-wrap:wrap;gap:10px;margin-top:27px}
.rd-link-button{background:#48627a;border:1px solid #48627a;padding:13px 18px;border-radius:9px;color:#fff;font-size:12px;font-weight:800;cursor:pointer;display:flex;gap:12px;align-items:center}
.rd-link-button.secondary{background:white;border-color:#cfdce9;color:#435d76}
.rd-reference-note{font-size:11px;line-height:1.75;color:#76879a;margin-top:23px}
.rd-empty{border:1px dashed #d4dfeb;border-radius:13px;padding:32px 20px;text-align:center;color:#67788c;font-size:13px}
.rd-empty[hidden]{display:none!important}
.rd-home-strip{max-width:1220px;margin:10px auto 52px;padding:30px 38px;background:#F2F6FB;border:1px solid #dce6ef;border-radius:17px;display:flex;justify-content:space-between;align-items:center;gap:30px}
.rd-home-strip h2{font:800 clamp(21px,3vw,30px) Manrope,Inter,sans-serif;letter-spacing:-.8px;color:#273a4e;margin:11px 0 8px}
.rd-home-strip p{font-size:13px;color:#607487;line-height:1.7;max-width:500px}
.rd-home-strip button{white-space:nowrap}
.rd-card-category{margin:6px 0 9px;font-size:10px;color:#5a7692}
.pc .rd-card-link{margin:10px 0 0;border:1px solid #dce5ee;background:#f7f9fb;color:#46627d;border-radius:8px;width:100%;min-height:37px;padding:10px 12px;text-align:left;font:800 11px 'DM Sans',Inter,Arial,sans-serif;display:flex;justify-content:space-between;align-items:center;cursor:pointer}
.pc .rd-card-link:hover{border-color:#718ca5;background:#eef3f8}
.rd-detail-button{width:100%;border:1px solid #bdcfe1;border-radius:8px;padding:12px 14px;margin:10px 0;color:#3d5c78;background:#f0f5fa;display:flex;align-items:center;justify-content:space-between;font:800 12px 'DM Sans',Inter,sans-serif;cursor:pointer}
.rd-detail-hint{font-size:10px;color:#677b8d;line-height:1.6;margin:6px 0 14px}
#pg-dosages .sr-only{position:absolute!important;width:1px!important;height:1px!important;overflow:hidden!important;clip:rect(0,0,0,0)!important;white-space:nowrap!important}
#pg-dosages .rd-card:target{outline:2px solid #7794b2;outline-offset:2px}
@media(max-width:1050px){.rd-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.rd-intro{gap:20px}}
@media(max-width:720px){.rd-wrap{padding:34px 18px 65px}.rd-intro{grid-template-columns:1fr;gap:19px}.rd-grid{grid-template-columns:1fr;gap:15px}.rd-card-head{min-height:117px}.rd-card-thumb{width:93px;height:90px}.rd-card-thumb img.vial-img{max-height:88px}.rd-card-body{padding:17px}.rd-summary{min-height:0}.rd-stat{min-height:0}.rd-filters{flex-wrap:nowrap;overflow-x:auto;padding-bottom:7px;scrollbar-width:thin}.rd-filter{flex:none}.rd-controls{padding:16px}.rd-result-line span:last-child{display:none}.rd-method{padding:22px 18px}.rd-method-grid{grid-template-columns:1fr;gap:12px}.rd-home-strip{margin:12px 18px 45px;padding:24px 20px;display:flex;flex-direction:column;align-items:stretch;gap:17px}.rd-home-strip button{align-self:stretch;justify-content:space-between}.rd-hero-counts span{font-size:10px}.rd-hero-counts strong{font-size:15px}}
@media(max-width:420px){.rd-card-head h3{font-size:18px}.rd-hero-counts{gap:6px}.rd-hero-counts span{padding:7px 9px}.rd-card-thumb{width:80px}}
@media(prefers-reduced-motion:reduce){.rd-expand-arrow,.rd-filter{transition:none}}